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Year : 2023  |  Volume : 20  |  Issue : 1  |  Page : 24-27

Chronic orofacial pain management: A narrative review of pharmacological and promising therapy

Department of Basic Sciences/Pharmacology, College of Dentistry, University of Babylon, Hillah, Iraq

Correspondence Address:
Malath Azeez Al-saadi
Department of Basic Sciences/Pharmacology, College of Dentistry, University of Babylon, Hilla, 51002, Babel
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_312_22

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Chronic orofacial pain is a multifactorial stressful condition. It devastates patients’ lives and depletes medical and dental services. Assertion of a particular effective pharmacological treatment is difficult due to psychological involvement and variation of pain etiology. Proper diagnosis plays a crucial role in determining the proper therapeutic agent. Pharmacological therapy is the first-line treatment of chronic orofacial pain with multiple drug classes to consider. This review aimed to focus on temporomandibular joint-related chronic orofacial pain as a common dental practice type of chronic pain and trigeminal neuralgia. Highlighting their effective and available pharmacological treatment and promising therapies. For mild-to-moderate pain, nonsteroidal anti-inflammatory drugs are preferred; however, pain chronicity requires another class that tends to modulate neurology- and psychology-associated factors. Common in-practice drugs are antidepressants and anticonvulsants. In most instances, the combination of different pharmacological treatments with a diverse mechanism of action is required for better pain control and reduced monotherapy-related adverse reaction. Opioids should reserve to severe pain and as dual therapy. Palmitoylethanolamide is a promising nutritional therapy that needs further research to establish its effect and safety.

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