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Year : 2023  |  Volume : 20  |  Issue : 1  |  Page : 212-214

Cytokines profile in patients with hydatidosis in Babylon Province, Iraq

1 Department of Microbiology, College of Dentistry, University of Babylon, Babylon, Iraq
2 Anesthesia Techniques Department, Al-Mustaqbal University College, Hillah, Iraq
3 Department of Nutrition, Babil Health Directorate, Hillah, Iraq
4 Department of Microbiology, College of Medicine, University of Babylon, Hillah, Babylon Province, Iraq

Correspondence Address:
Ahmed Mohammed A Al-Mosawi
Department of Microbiology, College of Dentistry, University of Babylon, Hillah, Babylon Province
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_305_22

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Background: Hydatidosis is caused by infection with the larval stage of the Cestode Echinococcus granulosus. Objective: In vitro quantitative evaluation of interleukin 6 (IL-6), INF-gamma (INF-γ), and CD4 and CD8 molecules during hydatidosis infection and control group. Materials and Methods: In vitro quantitative determination of IL-6, INF-γ, and CD4 and CD8 molecules in serum of hydatidosis-infected patients using serological test Sandwich-ELISA. Results: The result showed a significant difference in serum IL-6 in patients with hydatidosis than in the control group (38.753 ± 18.307 pg/mL) and 11.752 ± 3.328, respectively; the differences were highly significant (P < 0.0001). The mean of serum CD4 molecules concentration was 5.475 ± 2.335 (ng/mL) and 3.154 ± 1.027 (ng/mL) for controls groups with P value ≤ 0.0001, while serum concentration of soluble CD8 was 2.977 ± 1.321 (ng/mL) and 1.152 ± 0.699 (ng/mL) for control group with (P value ≤ 0.0001). The ratio of CD4/CD8 was 1.841 in hydatidosis infection patients compared with control group (2.737). Conclusion: Immunological parameters included in the present study (IL-6, IFN-γ, CD4 and CD8) showed high levels among patients with hydatidosis infection compared to healthy control.

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