| ORIGINAL ARTICLE |
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| Year : 2023 | Volume
: 20
| Issue : 1 | Page : 130-135 |
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The effect of coenzyme Q10 on dexamethasone-induced oxidative stress in rats testes
Ahmed T Alahmar1, Aqeel Handil Tarish Al Jothery2, Qasim Jawad Al-Daami3, Ahmed Abbas4, Alaa Tariq Shakir Al-Hassnawi4
1 Department of Medical Physiology, College of Medicine, University of Babylon, Babylon, Iraq
2 Department of Physiology, College of Veterinary Medicine, University of Kerbala, Karbala, Iraq
3 Department of Basic Sciences, College of Pharmacy, University of Babylon, Babylon, Iraq
4 Department of Biology, College of Science, University of Babylon, Babylon, Iraq
Correspondence Address:
Ahmed T Alahmar
Department of Medical Physiology, College of Medicine, University of Babylon, Babylon
Iraq
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/MJBL.MJBL_307_22
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Background: Oxidative stress is a contributing factor in 30%–80% of infertile men. Objective: The aim of this study was to investigate the impact of coenzyme Q10 on dexamethasone-induced oxidative stress in rats testes. Materials and Methods: Sixteen male Wistar rats were divided into four groups of four: group 1 (control) received 1 mL of distilled water daily orally; group 2 received dexamethasone 0.2 mg/kg/day intraperitoneally; group 3 received coenzyme Q10 30 mg/kg/day orally; and group 4 received dexamethasone and coenzyme Q10 via the same routes. Testicular total antioxidant capacity (TAC), superoxide dismutase (SOD), and catalase (CAT) activities as well as testicular histopathological changes were compared among groups. Results: Although testicular SOD was lower in groups 3 and 4, dexamethasone and coenzyme Q10 treatment did not significantly alter TAC, SOD, CAT, or histopathological features of rats testes. Conclusion: Dexamethasone (0.2 mg/kg/day) and coenzyme Q10 (30 mg/kg/day) may have no impact on gonadal oxidative stress, antioxidant capacity, or spermatogenesis in rats testes with these doses. |
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