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Year : 2022  |  Volume : 19  |  Issue : 4  |  Page : 714-720

The role of asprosin and ceramides in the development of growth hormone deficiency in children

College of Medicine, University of Babylon, Hilla, Iraq

Correspondence Address:
Muntadher Mohammad Al-Jubawi
College of Medicine, University of Babylon, Hilla
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_231_22

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Background: Growth hormone deficiency (GHD) is an endocrine condition, which is defined as a reduction in growth hormone (GH) synthesis; this study aims to evaluate the level of asprosin and ceramides in children (patients) with idiopathic isolated GHD. Materials and Methods: The present study was designed as a case–control study; 43 patients (24 males and 19 females) with idiopathic isolated GHD were involved in this study. Forty-five subjects (26 males and 19 females) who were apparently healthy control that enrolled in this study were matched with patients of the same sex and age. Results: The present study revealed a significant decrease (P < 0.05) in the levels of asprosin, ceramides, and glucose in patients with GHD when compared with its control group. Conclusions: Asprosin may be one of the underlying causes of GHD through its indirect role in releasing GH. GHD may decrease the level of ceramides by the effect of GH on lipid metabolism.

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