• Users Online: 940
  • Print this page
  • Email this page
Year : 2022  |  Volume : 19  |  Issue : 4  |  Page : 709-713

Accuracy of C-reactive protein and procalcitonin in differentiating between complicated and non-complicated acute appendicitis patients in Babylon province

Department of Chemistry and Biochemistry, College of Medicine, University of Babylon, Hilla, Iraq

Correspondence Address:
Raad Gazy Al Sehlany
Department of Chemistry and Biochemistry, College of Medicine, University of Babylon, Hilla
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_230_22

Rights and Permissions

Background: Clinical care may be influenced by the ability to predict whether a patient has complicated appendicitis at the time of presentation. However, it is unclear whether prehospital or in-hospital factors are associated with complicated appendicitis. We also want to know if C-reactive protein (CRP) and procalcitonin (PCT) can be used as supporting factors for Alvarado Score associated with complex appendicitis. Objectives: The aim of this study is to know the possibility of adding CRP and PCT to support the diagnostic protocol for differentiating between complicated acute appendicitis and noncomplicated acute appendicitis by knowing the sensitivity and specificity of each of them, as well as knowing which is more acceptable to add to the diagnostic protocol. Materials and Methods: A cross-sectional study was carried out in the Emergency Unit at AL-Hilla Teaching Hospital in Babylon province, Hilla city, between October 2021 and January 2022. There were a total of 90 patients; CRP and PCT were measured for patients by enzyme-linked immunosorbent assay method, in addition to knowing their Alvarado score. SPSS software was used to conduct the statistical analysis. Results: At the time of surgery, 34 (40%) of the 90 patients had complicated appendicitis, whereas 54 (60%) without complication. The age and gender of the groups did not show any significant difference. The Alvarado score, CRP, and PCT levels all showed a significant difference (P < 0.05). The correlation between Alvarado score and biochemical parameters (CRP and PCT) show a significant positive correlation. Conclusions: CRP and PCT support Alvarado score to differentiate between complicated acute appendicitis and noncomplicated acute appendicitis, and this is evident from the significantly higher concentrations of both in patients with complicated acute appendicitis than in patients with noncomplicated acute appendicitis.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded54    
    Comments [Add]    

Recommend this journal