• Users Online: 522
  • Print this page
  • Email this page
Year : 2022  |  Volume : 19  |  Issue : 3  |  Page : 409-414

The effect of Vit B12 deficiency, homocystein, and lipid metabolism in association with increased risk of gestational diabetes mellitus

Al-Imamain Al-Kadhemain Medical City, Baghdad, Iraq

Correspondence Address:
Kawakib Saeed Mahmood
Al-Imamain Al-Kadhemain Medical City, Baghdad
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_53_22

Rights and Permissions

Introduction: Gestational diabetes defined as carbohydrate intolerance of variable severity with onset or first recognition during the present pregnancy. This definition applies whether or not insulin is used for treatment and undoubtedly includes some women with previously unrecognized overt diabetes. Objectives: To assess the effect of Vit B12 deficiency, Homocystein and Lipid metabolism in association with increased risk of Gestational Diabetes Mellitus. Materials and Methods: A prospective case control study. Sample collection: pregnant women at the 2nd and 3rd trimester (n = 100) were divided into two groups: Women with GDM considered as case group (n = 50) and healthy pregnant women as control group (n = 50) were enrolled in this study. Results: The mean level of serum B12 in case group were (169.3 ± 13.6) and (227.5 ± 29.9) of control group with highly significant decrease in case group than that in healthy control group (P < 0.001). Significant correlation between Vit B12 and BMI, and significant association with moderate correlation with Gestational age (P- values =0.042). Significant association with moderate correlation between Vit B12 and both insulin level and HOMA-IR test in GDM group (P < 0.05) respectively. Highly significant association (P < 0.001) with good correlation (0.712) was found between Homocysteine and B12. Significant correlation between Vit B12 and lipid profile (cholesterol, LDL, HDL, and TG) and LDL, HDL, and TG were presented with moderate correlation. Homocysteine [umol/L] level in GDM group was (8.31 +/- 2.02) and (7.33 +/- 3.54) for healthy group with significant difference (P < 0.001). Conclusion: Highly significant decrease of vit B12 in patients with GDM than that in healthy group, while highly significant increase of Homocysteine and triglyceride in GDM patients than in healthy group.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded48    
    Comments [Add]    

Recommend this journal