• Users Online: 473
  • Print this page
  • Email this page
Year : 2022  |  Volume : 19  |  Issue : 3  |  Page : 318-323

Stem cells: Biology, types, polarity, and asymmetric cell division: A review

1 Medical Research Unit, Baghdad, Iraq
2 Anatomy Department, College of Medicine, Al-Nahrain University, Baghdad, Iraq

Correspondence Address:
Ghassaq T Alubaidi
Medical Research Unit, College of Medicine, Al-Nahrain University, 10001 Baghdad
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_34_22

Rights and Permissions

Applicability of stem cells in cell-based therapy and regenerative medicine provided hope for untreatable diseases; subsequently, stem cells bioengineering has become a promising scientific research topic. Different types of stem cells possess different characteristics; certain types are superior to others according to their advantages. Cell bias toward asymmetric division is the first step regarding tissue regeneration and homeostasis, and this event is stimulated by chemical and mechanical cues arising from the surrounding microenvironment. Inappropriate asymmetric cell division (ACD) consequently results in organ disrupt morphogenesis. Intracellular events including polar distribution of regulatory proteins and fate determinants are of significant importance to prepare cells toward asymmetric division. The assembly of polarity proteins on opposite sides of the cell would induce downstream signaling pathway, and this forms a fundamental mechanism to establish cell asymmetric division. This review addresses the current understanding regarding stem cells biology, niche-raised cues, and polarity of regularity proteins and fate determinants of ACD.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded94    
    Comments [Add]    

Recommend this journal