• Users Online: 972
  • Print this page
  • Email this page

Table of Contents
Year : 2022  |  Volume : 19  |  Issue : 2  |  Page : 129-132

Iatrogenic aortic dissection: A review

Department of Medicine, College of Medicine, al-Mustansiriyah University, Baghdad, Iraq

Date of Submission21-Apr-2022
Date of Acceptance27-Apr-2022
Date of Web Publication30-Jun-2022

Correspondence Address:
Abdulameer Jasim Jawad Al-Gburi
Department of Medicine, College of Medicine, al-Mustansiriyah University, Baghdad
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_60_22

Rights and Permissions

Acute aortic dissection (Stanford Type A) is a life-threatening medical emergency associated with a high rate of early mortality (57 percent) without surgical intervention. During coronary catheterization, it occurs at a rate of 0.02 percent to 0.06 percent. There are no clear guidelines regarding the optimal management of this fatal condition. The critical importance of preventing dissection propagation by stenting the dissection’s entrance in the coronary artery had been emphasized in prior review articles. Iatrogenic aortic dissections that do not involve the coronary arteries can be managed conservatively and closely followed-up with repeated imaging.

Keywords: Acute aortic dissection, iatrogenic acute aortic dissection, iatrogenic aortic dissection, iatrogenic ascending aortic dissection, Stanford Type A

How to cite this article:
Al-Gburi AJ. Iatrogenic aortic dissection: A review. Med J Babylon 2022;19:129-32

How to cite this URL:
Al-Gburi AJ. Iatrogenic aortic dissection: A review. Med J Babylon [serial online] 2022 [cited 2023 May 29];19:129-32. Available from: https://www.medjbabylon.org/text.asp?2022/19/2/129/349490

  Introduction Top

Acute aortic dissection (Stanford Type A) is an important medical emergency having a high rate of early mortality (57 percent) without surgical intervention.[1] The DeBakey and Stanford classification systems for aortic dissection are frequently used.[2],[3] The Stanford classification categorizes all dissections that involve the ascending aorta as type A, regardless of the primary intimal tear location, and all other aortic dissections as type B.[2],[3],[4],[5] Spontaneous dissection of the ascending aorta occurs nearly twice as frequently as descending dissections[6],[7],[8] and the right lateral ascending aortic wall is most commonly affected[9] with aortic arch involvement occurring in up to 30% of cases.[10] Dissection of the aorta caused by iatrogenic factors can occur infrequently as a catastrophic complication of coronary angioplasty.[11],[12]

Iatrogenic aortic dissection resulting from coronary catheterization occurs at a rate of 0.02 percent to 0.06 percent.[11],[12] It had been reported that the incidence of iatrogenic aortic dissection is 1.9 percent in difficult cases involving percutaneous coronary intervention on chronic total occlusion.[13] Unfortunately, there are no clear guidelines exist regarding the optimal management of this fatal condition.

The preferred treatment for spontaneous aortic dissection is surgical management.[1] Nevertheless, emergent surgical correction of iatrogenic aortic dissection after coronary angiography or percutaneous coronary interventions is especially difficult due to concurrent anticoagulants used during the procedure and myocardial ischemia caused by co-existing coronary artery disease.

  Review of Literature Top

Dunning et al[11] originally proposed a system of classification depending on the extension of involvement: Class 1 (4 patients) confined to the coronary cusp, Class 2 (3 patients) expand less than 4 cm up the ascending aorta, and Class 3 (2 patients) expand distally for more than 4 cm. Their study consists of nine patients with a cumulative incidence of 0.02 percent (0.19 percent in acute myocardial infarction). All nine cases involved an extended retrograde RCA dissection to the aortic root, and Amplatz guide catheters were used in 44% of cases. The four patients in Class 1 were treated successfully with the placement of a coronary stent and medical treatment. One of the Class 2 cases was effectively managed with emergency bypass surgery, while the other two were managed medically. While both Class 3 cases required emergency operation and died, both presented before catheterization with myocardial infarction. The authors suggest that Class 1 and Class 2 cases be treated with a coronary stent and/or medical treatment, while Class 3 cases should be treated surgically.

Numerous reports have discussed the advantages of non-surgically treating even severe iatrogenic aortic dissection resulting from percutaneous coronary intervention, using coronary stenting and/or conservative management[12],[14],[15],[16],[17],[18],[19],[20] as summarized in [Table 1]. Núñez-Gil et al. studied 74 patients who developed aortocoronary dissections as a result of cardiac catheterization (20% of whom had Dunning Class 3 dissections).[12] They demonstrated favorable outcomes with coronary stent and/or medical treatment, with 69 subjects (93 percent) remaining asymptomatic after a median of five years of follow-up. During early follow-up, only three patients (4%) need cardiac surgery and two (3%) died from aortic dissection sequelae. In five patients, subsequent imaging revealed a fully healed aorta (7 percent). The authors conclude that once the early critical phase of an iatrogenic aortic dissection is passed smoothly, the aorta heals completely without long-term complications and the dissection’s entrance into the coronary artery should be sealed with stenting. Iatrogenic aortic dissections that do not involve the coronary arteries can be managed conservatively and closely followed-up with repeated imaging, whereas those with significant symptoms, propagating dissections, or obstructing the coronary flow may require surgical intervention.
Table 1: Summary of reports suggesting the advantages of non-surgically treating even severe iatrogenic aortic dissection resulting from percutaneous coronary intervention, using coronary stenting and/or conservative management

Click here to view

The critical importance of preventing dissection propagation by stenting the dissection’s entrance in the coronary artery had been emphasized in prior review articles of iatrogenic Stanford type A aortic dissections.[14],[15] Shah et al[14] included in their study 86 patients, 65 (76%) of them had undergone placement of a coronary stent and/or medical treatment, with three patients died. Aortic repair alone or in conjunction with coronary artery bypass grafting was done in the remained 21 (24%) patients. Three patients died among those who had undergone surgical treatment. Carstensen et al[15] included in their study 67 patients, 55 (82 percent) of them undergone coronary stent and/or medical treatment. There were two deaths (4%) in those managed non-surgically and three deaths (25%) in those managed surgically.

Additionally, Yip et al[21] describe a case series of 7 patients, 6 of them had a retrograde iatrogenic dissection of the aorta from the right coronary artery and one from the left coronary arteries to the ipsilateral coronary sinus, which was the result of balloon inflation in five cases, guiding catheter in one case, and thrombectomy catheter in one case. In five patients, iatrogenic aortic dissection was localized to the coronary sinus and expanded into the ascending part of the aorta in two. All five patients of the localized type were successfully treated with the placement of a coronary stent. A Thallium perfusion scan six months later revealed a defect in perfusion in two patients with angina and right coronary artery restenosis on coronary angiography. The remaining three individuals had normal scans and without symptoms. Placement of a coronary stent was failed in one patient with the extended type, who then declined surgery and died. The other patient required emergency surgery and was successfully treated. The authors conclude that prompt coronary stenting should be performed to seal the aortocoronary dissection’s entry site and avoid its extension, and surgical management is necessary for those with severe iatrogenic aortic dissection and the development of complications. Placement of a coronary stent remains beneficial for patients’ stabilization before surgery.

Another recent case report[22] emphasizes the critical importance of using the appropriate imaging (CT scan) to secure a correct diagnosis when iatrogenic aortic dissection is suspected but missed on conventional contrast images, as well as the critical role of hemodynamic control.

Gryko et al[23] present a case of unstable angina with the previous implantation of a drug-eluting stent for the left circumflex artery and admitted later for planned coronary angiography due to the recurrence of chest pain (Canadian Cardiovascular Society class III). Utilizing the right radial approach, Coronary angiography was done that revealed a 90 percent stenosis. Aortic sinus dissection occurred during right coronary artery engagement using Amplatz Left catheter. The patient’s hemodynamic status remained stable without symptoms. Then, two stents were implanted, the first sealing the dissection’s entry site and the second distally using a guide extension catheter to minimize any trauma. Nitroglycerin infusion and a beta-blocker were used. The patient was discharged twelve days after percutaneous coronary intervention. A follow-up CT revealed a complete resolution of the hematoma after one month.

Another case report by Okuyama et al[24] with a previous Stanford B aortic dissection undergoing coronary angiography for left ventricular dysfunction. Coronary dissection was noted in the right coronary artery ostium and progressively extended during percutaneous coronary intervention. The next day, despite the absence of symptoms, computed tomography was done and revealed a massive aortic dissection and gradual expansion of the false lumen. They performed a second percutaneous coronary intervention one week after the first one, using a stent dilated to 6.0 mm. The false lumen had disappeared completely three weeks after the second percutaneous coronary intervention.

The trans-radial approach is increasing in popularity in recent years because of its benefit over the femoral approach, which results in less patient discomfort and less bleeding, the ability to walk following the procedure, a short hospital stay, and even the same-day discharge. Another case report by Eshraghi et al[25] using a radial approach in a patient with a positive exercise ECG test. During coronary angiography and following the initial right coronary artery contrast injection, aortic dissection was noted with expansion to the ascending aorta with the development of chest pain. After a few minutes, the chest pain subsided and the ECG revealed no evidence of ischemia. Additionally, computed tomography reveals no aortic dissection or hematoma. The decision was made to use a watch-and-wait strategy with intensive antihypertensive therapy. After eight hours, chest pain was felt by the patient. The ECG revealed a junctional rhythm with no evidence of ischemia. After six hours, the blood pressure decreased and an ECG revealed atrial fibrillation, and coronary angiography was repeated using the radial approach. Right coronary injection demonstrated significant ostial narrowing. There was no SA node artery. From the ostium to the proximal right coronary artery, a stent was implanted with the restoration of normal flow. Two hours later, the patient’s ECG showed a normal sinus rhythm with no chest pain.

There are several possible mechanisms responsible for this catastrophic event. Catheter trauma appears to cause dissection of the coronary artery with later retrograde progression into the aortic root via the subintima. Vigorous contrast medium injection by hand, improper catheter manipulation, and subintimal guidewire passage all have been suggested as causes of iatrogenic coronary dissection.[21] Cystic media necrosis, congenital bicuspid and unicuspid aortic valves, atherosclerosis, Marfan syndrome, and hypertension are all risk factors.[11],[26] It had been reported that the risk of proximal right coronary artery dissection increased with the use of EBU, Amplatz or Kimny guide catheter, atherosclerotic plaque presence, angulation of the proximal segment, and the presence of calcification.[27]

A large percentage of patients who develop spontaneous aortic dissection have a pre-existing aortic disease. In comparison, patients with iatrogenic aortic dissection may have relatively normal aortic walls, which may allow for improved healing once the aortic dissection’s entry site is sealed. Additionally, advanced atherosclerosis may constrict the plane of dissection. This may explain that patients with iatrogenic aortic dissection frequently respond favorably to stenting and/or conservative therapy.

  Conclusion Top

As percutaneous coronary intervention has become more aggressive in the chronic total occlusion era, more and more complications have arisen from either aggressive guiding catheter use, wire trauma, or subintimal dissection near the coronary ostium resulting in aortic dissection. The aortic dissection incidence in a multicenter registry was 0.06% and was typically caused by catheter trauma. Sealing the breach as the site of coronary ostium with a stent stabilizes the dissection. The great majority of these dissections can be treated conservatively.

Ethical consideration

Not applicable

Financial support and sponsorship

None to be declared

Conflicts of interest

Conflicts of interest do not exist.

  References Top

Pape LA, Awais M, Woznicki EM, Suzuki T, Trimarchi S, Evangelista A, et al. Presentation, diagnosis, and outcomes of acute aortic dissection: 17-year trends from the international registry of acute aortic dissection. J Am Coll Cardiol 2015;66:350-8.  Back to cited text no. 1
Daily PO, Trueblood HW, Stinson EB, Wuerflein RD, Shumway NE Management of acute aortic dissections. Ann Thorac Surg 1970;10:237-47.  Back to cited text no. 2
Debakey ME, Henly WS, Cooley DA, Morris GC, Crawford ES, Beall AC Surgical management of dissecting aneurysms of the aorta. The Journal of Thoracic and Cardiovascular Surgery 1965;49:130-49.  Back to cited text no. 3
Nienaber CA, Eagle KA Aortic dissection: New frontiers in diagnosis and management: Part I: From etiology to diagnostic strategies. Circulation 2003;108:628-35.  Back to cited text no. 4
Tsai TT, Nienaber CA, Eagle KA Acute aortic syndromes. Circulation 2005;112:3802-13.  Back to cited text no. 5
Song JK, Kim HS, Song JM, Kang DH, Ha JW, Rim SJ, et al. Outcomes of medically treated patients with aortic intramural hematoma. Am J Med 2002;113:181-7.  Back to cited text no. 6
Evangelista A, Mukherjee D, Mehta RH, O’Gara PT, Fattori R, Cooper JV, et al; International Registry of Aortic Dissection (IRAD) Investigators. Acute intramural hematoma of the aorta: A mystery in evolution. Circulation 2005;111:1063-70.  Back to cited text no. 7
Harris KM, Braverman AC, Eagle KA, Woznicki EM, Pyeritz RE, Myrmel T, et al. Acute aortic intramural hematoma: An analysis from the international registry of acute aortic dissection. Circulation 2012;126:S91-6.  Back to cited text no. 8
Larson EW, Edwards WD Risk factors for aortic dissection: A necropsy study of 161 cases. Am J Cardiol 1984;53:849-55.  Back to cited text no. 9
Nienaber CA, Eagle KA Aortic dissection: New frontiers in diagnosis and management: Part Ii: Therapeutic management and follow-up. Circulation 2003;108:772-8.  Back to cited text no. 10
Dunning DW, Kahn JK, Hawkins ET, O’Neill WW Iatrogenic coronary artery dissections extending into and involving the aortic root. Catheter Cardiovasc Interv 2000;51:387-93.  Back to cited text no. 11
Núñez-Gil IJ, Bautista D, Cerrato E, Salinas P, Varbella F, Omedè P, et al; Registry on Aortic Iatrogenic Dissection (RAID) Investigators. Incidence, management, and immediate- and long-term outcomes after iatrogenic aortic dissection during diagnostic or interventional coronary procedures. Circulation 2015;131:2114-9.  Back to cited text no. 12
El Sabbagh A, Patel VG, Jeroudi OM, Michael TT, Alomar ME, Mogabgab O, et al. Angiographic success and procedural complications in patients undergoing retrograde percutaneous coronary chronic total occlusion interventions: A weighted meta-analysis of 3,482 patients from 26 studies. Int J Cardiol 2014;174:243-8.  Back to cited text no. 13
Shah P, Bajaj S, Shamoon F Aortic dissection caused by percutaneous coronary intervention: 2 new case reports and detailed analysis of 86 previous cases. Tex Heart Inst J 2016;43:52-60.  Back to cited text no. 14
Carstensen S, Ward MR Iatrogenic aortocoronary dissection: The case for immediate aortoostial stenting. Heart Lung Circ 2008;17:325-9.  Back to cited text no. 15
Abbasi MA, Hur DJ, Goldsweig AM Large iatrogenic aortic dissection from percutaneous coronary intervention resolved in 4 days. J Vasc Surg Cases Innov Tech 2020;6:12-3.  Back to cited text no. 16
Chi WK, Tse G, Yan BP Successful conservative management of class Iii iatrogenic aortic dissection. J Geriatr Cardiol 2018;15:235-7.  Back to cited text no. 17
Roumy A, Kirsch M, Prêtre R, Niclauss L Spontaneous regression of a large iatrogenic dissection of the ascending aorta. Aorta (Stamford) 2016;4:226-8.  Back to cited text no. 18
Tam DY, Mazine A, Cheema AN, Yanagawa B Conservative management of extensive iatrogenic aortic dissection. Aorta (Stamford) 2016;4:229-31.  Back to cited text no. 19
Zafar MA, Pang PYK, Henry GA, Ziganshin BA, Tranquilli M, Elefteriades JA Early spontaneous resolution of an iatrogenic acute type A aortic dissection. Aorta (Stamford) 2016;4:235-9.  Back to cited text no. 20
Yip HK, Wu CJ, Yeh KH, Hang CL, Fang CY, Hsieh KY, et al. Unusual complication of retrograde dissection to the coronary sinus of valsalva during percutaneous revascularization: A single-center experience and literature review. Chest 2001;119:493-501.  Back to cited text no. 21
Sherif M, Jhala H, Chetty G Managing iatrogenic aortic dissection during primary percutaneous coronary intervention of the left main stem. J Card Surg 2022;37:1402-4.  Back to cited text no. 22
Gryko AB, Chlabicz M, Jakim P, Nowak KS, Bachórzewska-Gajewska H, Dobrzycki S Non-surgical management of iatrogenic aortic dissection (dunning class 3) caused by percutaneous coronary intervention. Postepy Kardiol Interwencyjnej 2021;17:423-4.  Back to cited text no. 23
Okuyama T, Maehara T, Kamba T, Fukushima K, Yoshida R, Oki Y, et al. Massive iatrogenic aortic dissection during percutaneous coronary intervention. Circ J 2021;85:1101.  Back to cited text no. 24
Eshraghi A, Jalalyazdi M, Ramezani J, Baburian M Late presentation of iatrogenic dissection of right coronary cusp: A case report. J Cardiovasc Thorac Res 2020;12:341-4.  Back to cited text no. 25
Gur M, Yilmaz R, Demirbag R, Kunt AS Large atherosclerotic plaque related severe right coronary artery dissection during coronary angiography. Int J Cardiovasc Imaging 2006;22: 321-5.  Back to cited text no. 26
Chai HT, Yang CH, Wu CJ, Hang CL, Hsieh YK, Fang CY, et al. Utilization of a double-wire technique to treat long extended spiral dissection of the right coronary artery. Evaluation of incidence and mechanisms. Int Heart J 2005;46:35-44.  Back to cited text no. 27


  [Table 1]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Review of Literature
Article Tables

 Article Access Statistics
    PDF Downloaded146    
    Comments [Add]    

Recommend this journal