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Year : 2019  |  Volume : 16  |  Issue : 2  |  Page : 89-93

Interaction of sodium dodecyl sulfate with anticancer drug 6-mercaptopurine

1 Department of Pharmaceutics, Faculty of Pharmacy, Kufa University, Najaf, Iraq
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kufa University, Najaf, Iraq
3 Department of Chemistry, Faculty of Science, Kufa University, Najaf, Iraq

Correspondence Address:
Alaa A Habeeb
Department of Pharmaceutics, Faculty of Pharmacy, Kufa University, Najaf
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJBL.MJBL_3_19

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Background: 6-Mercaptopurine (6-MP) is used in the conventional chemotherapy of patients with acute lymphoblastic leukemia. Materials and Methods: Sodium dodecyl sulfate (SDS), an anionic surfactant that is commonly used to mimic hydrophobic binding environments such as cell membranes, micellization behavior of sodium dodecyl sulfate (anionic surfactant) has been studied in the presence of 6-MP (anticancer drug) at (1 × 10−5 M) concentrations with different time periods in micelle solution, studied at 37°C. Results: The results showed increase the absorbance values for the pharmaceutical compound (6-MP). Increase the absorbance values of pharmaceutical compounds with 1 × 10−2 critical micelle concentration values of surfactant increase of 6-MP concentrations in micelle solution, with decrease its concentrations in organic media, various thermo-dynamic parameters such as standard-free energy of micellization ΔG (0.6216 k J.mol−1), that have direct bearing on the consequences of such interactions at the molecular level have been calculated. Depend on Keq and slope values for reversible reactions. Conclusion: The above-calculated parameters were found to be sensitive toward the interactions prevailing in 6-MP–SDS–hexane-water systems. After fixed the experimental optimum conditions at pH 7.4, 37°C, and λmax 322 nm.

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