| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 15
| Issue : 1 | Page : 48-52 |
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Immune profile in aborted Iraqi women with toxoplasmosis
Muhammed Abdul-Gabar Hamoodi Aldabagh1, Sadeq Kadhin Hachim2, Khalid Waleed Qassim3, Qasim Sharhan Al-Mayah1, Jabbar Salman Hassan4, Dunya Fareed Salloom5
1 Medical Research Unit, College of Medicine, Al-Nahrain University, Baghdad, Iraq
2 Medical Technical Institute, Baghdad, Middle Technical University, Baghdad, Iraq
3 Department of Pathology, College of Medicine, Al-Nahrain University, Baghdad, Iraq
4 Department of Medical Microbiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq
5 Department of Biology, College of Science, Baghdad University, Baghdad, Iraq
Correspondence Address:
Muhammed Abdul-Gabar Hamoodi Aldabagh
Medical Research Unit, College of Medicine, Al-Nahrain University, Baghdad
Iraq
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/MJBL.MJBL_13_18
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Background: Toxoplasmosis is one of the most important causes for abortion in women. The immune responses have a role in the outcome of such infection in gestated women. Aim: The current study was designed to investigate the immune profile in aborted Iraqi women with toxoplasmosis. Materials and Methods: Fifty-five aborted women and 29 healthy control women were enrolled in this study. Enzyme-linked immunosorbent assays were used to estimate serum levels to each of interleukin-1 alpha (IL-1α), granulocyte-monocyte colony-stimulating factor, IL-8, IL-4 IL-10, IL-12, interferon gamma (INF-γ), and IL-6. Single-radial-immunodiffusion assay was used to estimate serum levels of C3, C4, and total immunoglobulin gamma. Results: Serum levels of IL-8 showed significant elevation, while IL-6 and INF-γ showed significant dropping in infected women compared to control. Other immune factors showed nonsignificant differences between the two groups of the present study. Conclusion: Disturbance of immune response associated with toxoplasmosis may explain the success of parasite in escaping from discrimination and elimination by the immune system then supporting its survival and replication.
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